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Sex-specific association between prenatal androgenization (second-to-fourth digit length ratio) and frontal brain volumes in adolescents
Lenz, Bernd
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Gerhardt, Sarah
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Boroumand-Jazi, Rafat
;
Eichler, Anna
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Buchholz, Verena Nadine
;
Fasching, Peter A.
;
Kornhuber, Johannes
;
Banaschewski, Tobias
;
Flor, Herta
;
Guldner, Stella
;
Prignitz, Maren
;
Nees, Frauke
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DOI:
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https://doi.org/10.1007/s00406-022-01515-4
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URL:
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https://link.springer.com/article/10.1007/s00406-0...
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URN:
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urn:nbn:de:bsz:180-madoc-703696
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Document Type:
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Article
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Year of publication:
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2023
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The title of a journal, publication series:
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European Archives of Psychiatry and Clinical Neuroscience
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Volume:
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273
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Issue number:
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6
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Page range:
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1243-1254
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Place of publication:
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Berlin ; Darmstadt
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Publishing house:
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Springer ; Steinkopff
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ISSN:
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0940-1334 , 1433-8491
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Publication language:
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English
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Institution:
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School of Social Sciences > Klinische Psychologie, Interaktions- und Psychotherapieforschung (Aguilar-Raab 2023-)
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Pre-existing license:
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 Creative Commons Attribution 4.0 International (CC BY 4.0)
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Subject:
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150 Psychology
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Keywords (English):
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digit ratio , anterior cingulate gyrus , inferior frontal gyrus , behavioral control , sex , gender
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Abstract:
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Prenatal androgenization associates sex-dependently with behavior and mental health in adolescence and adulthood, including risk-taking, emotionality, substance use, and depression. However, still little is known on how it affects underlying neural correlates, like frontal brain control regions. Thus, we tested whether prenatal androgen load is sex-dependently related to frontal cortex volumes in a sex-balanced adolescent sample. In a cross-sectional magnetic resonance imaging study, we examined 61 adolescents (28 males, 33 females; aged 14 or 16 years) and analyzed associations of frontal brain region volumes with the second-to-fourth digit length ratio (2D:4D), an established marker for prenatal androgenization, using voxel-based morphometry in a region-of-interest approach. Lower 2D:4D (indicative of higher prenatal androgen load) correlated significantly with smaller volumes of the right anterior cingulate cortex (r-ACC; β = 0.45) in male adolescents and with larger volumes of the left inferior frontal gyrus orbital part (l-IFGorb; β = – 0.38) in female adolescents. The regression slopes of 2D:4D on the r-ACC also differed significantly between males and females. The study provides novel evidence that prenatal androgenization may influence the development of the frontal brain in a sex- and frontal brain region-specific manner. These effects might contribute to the well-known sex differences in risk-taking, emotionality, substance use, and depression. Future research is needed to elucidate the role of prenatal androgenization within the biopsychosocial model.
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 | Das Dokument wird vom Publikationsserver der Universitätsbibliothek Mannheim bereitgestellt. |
 | Dieser Datensatz wurde nicht während einer Tätigkeit an der Universität Mannheim veröffentlicht, dies ist eine Externe Publikation. |
 Search Authors in
BASE:
Lenz, Bernd
;
Gerhardt, Sarah
;
Boroumand-Jazi, Rafat
;
Eichler, Anna
;
Buchholz, Verena Nadine
;
Fasching, Peter A.
;
Kornhuber, Johannes
;
Banaschewski, Tobias
;
Flor, Herta
;
Guldner, Stella
;
Prignitz, Maren
;
Nees, Frauke
Google Scholar:
Lenz, Bernd
;
Gerhardt, Sarah
;
Boroumand-Jazi, Rafat
;
Eichler, Anna
;
Buchholz, Verena Nadine
;
Fasching, Peter A.
;
Kornhuber, Johannes
;
Banaschewski, Tobias
;
Flor, Herta
;
Guldner, Stella
;
Prignitz, Maren
;
Nees, Frauke
ORCID:
Lenz, Bernd ; Gerhardt, Sarah ; Boroumand-Jazi, Rafat ; Eichler, Anna ; Buchholz, Verena Nadine ; Fasching, Peter A. ; Kornhuber, Johannes ; Banaschewski, Tobias ; Flor, Herta ; Guldner, Stella  ORCID: 0000-0001-7060-7711 ; Prignitz, Maren ORCID: 0000-0001-5896-2294 ; Nees, Frauke
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