Is auditory evoked potential augmenting/reducing affected by acute trypthophan depletion?

Debener, Stefan ; Strobel, Alexander ; Kuerschner, Katharina ; Kranczioch, Cornelia ; Hebenstreit, Jörg ; Maercker, Andreas ; Beauducel, André ; Brocke, Burkhard

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Document Type: Article
Year of publication: 2002
The title of a journal, publication series: Biological Psychology
Volume: 59
Issue number: 2
Page range: 121-133
Place of publication: Amsterdam [u.a.]
Publishing house: Elsevier
ISSN: 0301-0511 , 1873-6246
Publication language: English
Institution: School of Social Sciences > Psychologie II (Wittmann 1993-2009, Em)
Subject: 150 Psychology
Abstract: Several lines of evidence suggest that the auditory evoked potential (AEP) augmenting/reducing slope may serve as a biological marker of central serotonergic activity. According to Hegerl and Juckel (Biol. Psychiatry, 33, 1993, 173), reduced serotonergic activity is hypothesized to increase the slope of the AEP amplitude stimulus intensity function (ASF-slope). Hints for this hypothesis were investigated by employing the acute tryptophan depletion paradigm in 18 healthy females. A within-subject, placebo controlled double-blind cross over design was used for that purpose. Subjects ingested both a 50 g amino-acid drink with (placebo condition) and without tryptophan (depletion condition). With respect to the N1/P2-slope, testretest reliability of a 1 week interval ranged between r

Dieser Eintrag ist Teil der Universitätsbibliographie.

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