Chromosomal instability and bladder cancer: the UroVysionTM test in the UroScreen study

Bonberg, Nadine ; Taeger, Dirk ; Gawrych, Katarzyna ; Johnen, Georg ; Banek, Séverine ; Schwentner, Christian ; Sievert, Karl-Dietrich ; Wellhäußer, Harald ; Kluckert, Matthias ; Leng, Gabriele ; Nasterlack, Michael ; Stenzl, Arnulf ; Behrens, Thomas ; Brüning, Thomas ; Pesch, Beate

Document Type: Article
Year of publication: 2013
The title of a journal, publication series: BJU International : BJUI
Volume: 112
Issue number: 4
Page range: E372-E382
Place of publication: Oxford
Publishing house: Wiley-Blackwell
ISSN: 1464-410X
Publication language: English
Institution: Business School > ABWL, Personalmanagement u. Führung (Biemann 2013-)
Subject: 610 Medicine and health
Keywords (English): bladder cancer , urine , chromosomal instability , UroVysion , fluorescence in situ hybridisation
Abstract: What’s known on the subject? and What does the study add? UroVysion™ is a multicolour fluorescence in situ hybridisation assay that detects DNA gain at chromosomes 3, 7 and 17 and loss at the 9p21 locus in exfoliated urothelial cells. This cell-based test is time-consuming and costly compared with voided urine cytology or other molecular markers for the early detection of bladder cancer. We determined copy number changes at chromosomes 3, 7 and 17 and at the 9p21 locus with UroVysion in a prospective screening study among chemical workers. Strong correlations between DNA gains yield a similar performance in detecting bladder cancer with just one of the probes for chromosomes 3, 7 or 17 instead of all, supporting the development of a simpler and cheaper assay.

Dieser Eintrag ist Teil der Universitätsbibliographie.

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