Chromosomal instability and bladder cancer: the UroVysionTM test in the UroScreen study

DOI:	https://doi.org/10.1111/j.1464-410X.2012.11666.x
URL:	http://onlinelibrary.wiley.com/doi/10.1111/j.1464-...
Document Type:	Article
Year of publication:	2013
The title of a journal, publication series:	BJU International : BJUI
Volume:	112
Issue number:	4
Page range:	E372-E382
Place of publication:	Oxford
Publishing house:	Wiley-Blackwell
ISSN:	1464-410X
Publication language:	English
Institution:	Business School > ABWL, Personalmanagement u. Führung (Biemann 2013-)
Subject:	610 Medicine and health
Keywords (English):	bladder cancer , urine , chromosomal instability , UroVysion , fluorescence in situ hybridisation
Abstract:	What’s known on the subject? and What does the study add? UroVysion™ is a multicolour fluorescence in situ hybridisation assay that detects DNA gain at chromosomes 3, 7 and 17 and loss at the 9p21 locus in exfoliated urothelial cells. This cell-based test is time-consuming and costly compared with voided urine cytology or other molecular markers for the early detection of bladder cancer. We determined copy number changes at chromosomes 3, 7 and 17 and at the 9p21 locus with UroVysion in a prospective screening study among chemical workers. Strong correlations between DNA gains yield a similar performance in detecting bladder cancer with just one of the probes for chromosomes 3, 7 or 17 instead of all, supporting the development of a simpler and cheaper assay.

Dieser Eintrag ist Teil der Universitätsbibliographie.

BASE: Bonberg, Nadine ; Taeger, Dirk ; Gawrych, Katarzyna ; Johnen, Georg ; Banek, Séverine ; Schwentner, Christian ; Sievert, Karl-Dietrich ; Wellhäußer, Harald ; Kluckert, Matthias ; Leng, Gabriele ; Nasterlack, Michael ; Stenzl, Arnulf ; Behrens, Thomas ; Brüning, Thomas ; Pesch, Beate

Google Scholar: Bonberg, Nadine ; Taeger, Dirk ; Gawrych, Katarzyna ; Johnen, Georg ; Banek, Séverine ; Schwentner, Christian ; Sievert, Karl-Dietrich ; Wellhäußer, Harald ; Kluckert, Matthias ; Leng, Gabriele ; Nasterlack, Michael ; Stenzl, Arnulf ; Behrens, Thomas ; Brüning, Thomas ; Pesch, Beate

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