Neurodevelopmental outcome in children with single ventricle after total cavopulmonary connection

Vahsen, Nicole ; Bröder, Arndt ; Hraska, Viktor ; Schneider, Martin

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Document Type: Article
Year of publication: 2018
The title of a journal, publication series: Klinische Pädiatrie
Volume: 230
Issue number: 1
Page range: 24-30
Place of publication: Stuttgart
Publishing house: Thieme
ISSN: 0300-8630 , 1439-3824
Publication language: English
Institution: School of Social Sciences > Allgemeine Psychologie (Bröder 2010-)
Subject: 150 Psychology
Abstract: Background: The purpose of the present study was to assess a broad range of neuropsychological outcome variables in children with functionally single ventricle hearts after a total cavopulmonary connection and to examine potential risk factors for impaired neurodevelopment. Patients & Method: A total of 104 patients aged 2 to 20 years underwent follow-up standardized psychological testing, including measures of intelligence, motor function, visuospatial abilities, behavioural outcome and health-related quality of life. Results: With a mean fluid intelligence score of 93.0 and a mean crystallized intelligence score of 92.3, patients scored significantly lower on tests of intelligence compared to the general population (p<0.001). Reduced motor function was found in 34% of the patients (p<0.001), impaired visuospatial abilities in 51%; parents reported significantly more behavioural problems (p<0.001). There was no difference in the self-reported quality of life compared to the general population. Risk factors for reduced fluid intelligence were deep hypothermic circulatory arrest times (p=0.03) and complications causing suboptimal brain perfusion prior to the total cavopulmonary connection (e. g. seizures; p=0.04). Conclusions: Patients with functionally single ventricle hearts palliated with a total cavopulmonary connection are at an increased risk of neurodevelopmental delays and behavioural disorders. Nevertheless, they adapt well in terms of quality of life. Early diagnostics and interventions are necessary when developmental delays are suspected.

Dieser Eintrag ist Teil der Universitätsbibliographie.

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