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An investigation of genetic variability of DNA methyltransferases DNMT3A and 3B does not provide evidence for a major role in the pathogenesis of panic disorder and dimensional anxiety phenotypes
Berking, Ann-Cathrine
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Thiel, Christiane
;
Schiele, Miriam A.
;
Baumann, Christian
;
Kalisch, Raffael
;
Notzon, Swantje
;
Zwanzger, Peter
;
Pané-Farré, Christiane A.
;
Hamm, Alfons O.
;
Alpers, Georg W.
;
Fydrich, Thomas
;
Fehm, Lydia
;
Gerlach, Alexander L.
;
Straube, Benjamin
;
Kircher, Tilo
;
Rief, Winfried
;
Plag, Jens
;
Ströhle, Andreas
;
Lang, Thomas
;
Wittchen, Hans-Ulrich
;
Arolt, Volker
;
Romanos, Marcel
;
Pauli, Paul
;
Reif, Andreas
;
Deckert, Jürgen
;
Domschke, Katharina
;
Weber, Heike
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DOI:
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https://doi.org/10.1007/s00702-020-02206-x
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URL:
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https://link.springer.com/article/10.1007/s00702-0...
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Additional URL:
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https://www.researchgate.net/publication/341737800...
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Document Type:
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Article
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Year of publication:
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2020
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The title of a journal, publication series:
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Journal of Neural Transmission
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Volume:
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127
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Issue number:
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11
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Page range:
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1527-1537
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Place of publication:
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Wien [u.a.]
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Publishing house:
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Springer
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ISSN:
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0300-9564 , 1435-1463
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Related URLs:
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Publication language:
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English
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Institution:
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School of Social Sciences > Klinische u. Biologische Psychologie u. Psychotherapie (Alpers 2010-)
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Subject:
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150 Psychology
610 Medicine and health
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Abstract:
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While DNA methylation patterns have been studied for a role in the pathogenesis of anxiety disorders, the role of the enzymes establishing DNA methylation—DNA methyltransferases (DNMTs)—has yet to be investigated. In an effort to investigate DNMT genotype-specific effects on dimensional anxiety traits in addition to the categorical phenotype of panic disorder, 506 panic disorder patients and 3112 healthy participants were assessed for anxiety related cognition [Agoraphobic Cognitions Questionnaire (ACQ)], anxiety sensitivity [Anxiety Sensitivity Index (ASI)] as well as pathological worry [Penn State Worry Questionnaire (PSWQ)] and genotyped for five single nucleotide polymorphisms (SNPs) in the DNMT3A (rs11683424, rs1465764, rs1465825) and DNMT3B (rs2424932, rs4911259) genes, which have previously been found associated with clinical and trait-related phenotypes. There was no association with the categorical phenotype panic disorder. However, a significant association was discerned between DNMT3A rs1465764 and PSWQ scores in healthy participants, with the minor allele conveying a protective effect. In addition, a marginally significant association between questionnaire scores (PSWQ, ASI) in healthy participants and DNMT3B rs2424932 was detected, again with the minor allele conveying a protective effect. The present results suggest a possible minor role of DNMT3A and DNMT3B gene variation in conveying resilience towards anxiety disorders. As the observed associations indicated a protective effect of two SNPs particularly with pathological worry, future studies are proposed to explore these variants in generalized anxiety disorder rather than panic disorder.
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Additional information:
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Fälschl. "Notzen, Swantje" statt "Notzon, Swantje"
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 | Dieser Eintrag ist Teil der Universitätsbibliographie. |
 Search Authors in
BASE:
Berking, Ann-Cathrine
;
Thiel, Christiane
;
Schiele, Miriam A.
;
Baumann, Christian
;
Kalisch, Raffael
;
Notzon, Swantje
;
Zwanzger, Peter
;
Pané-Farré, Christiane A.
;
Hamm, Alfons O.
;
Alpers, Georg W.
;
Fydrich, Thomas
;
Fehm, Lydia
;
Gerlach, Alexander L.
;
Straube, Benjamin
;
Kircher, Tilo
;
Rief, Winfried
;
Plag, Jens
;
Ströhle, Andreas
;
Lang, Thomas
;
Wittchen, Hans-Ulrich
;
Arolt, Volker
;
Romanos, Marcel
;
Pauli, Paul
;
Reif, Andreas
;
Deckert, Jürgen
;
Domschke, Katharina
;
Weber, Heike
Google Scholar:
Berking, Ann-Cathrine
;
Thiel, Christiane
;
Schiele, Miriam A.
;
Baumann, Christian
;
Kalisch, Raffael
;
Notzon, Swantje
;
Zwanzger, Peter
;
Pané-Farré, Christiane A.
;
Hamm, Alfons O.
;
Alpers, Georg W.
;
Fydrich, Thomas
;
Fehm, Lydia
;
Gerlach, Alexander L.
;
Straube, Benjamin
;
Kircher, Tilo
;
Rief, Winfried
;
Plag, Jens
;
Ströhle, Andreas
;
Lang, Thomas
;
Wittchen, Hans-Ulrich
;
Arolt, Volker
;
Romanos, Marcel
;
Pauli, Paul
;
Reif, Andreas
;
Deckert, Jürgen
;
Domschke, Katharina
;
Weber, Heike
ORCID:
Berking, Ann-Cathrine ; Thiel, Christiane ; Schiele, Miriam A. ; Baumann, Christian ; Kalisch, Raffael ; Notzon, Swantje ; Zwanzger, Peter ; Pané-Farré, Christiane A. ; Hamm, Alfons O. ; Alpers, Georg W.  ORCID: 0000-0001-9896-5158 ; Fydrich, Thomas ; Fehm, Lydia ; Gerlach, Alexander L. ; Straube, Benjamin ; Kircher, Tilo ; Rief, Winfried ; Plag, Jens ; Ströhle, Andreas ; Lang, Thomas ; Wittchen, Hans-Ulrich ; Arolt, Volker ; Romanos, Marcel ; Pauli, Paul ; Reif, Andreas ; Deckert, Jürgen ; Domschke, Katharina ; Weber, Heike
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