An investigation of genetic variability of DNA methyltransferases DNMT3A and 3B does not provide evidence for a major role in the pathogenesis of panic disorder and dimensional anxiety phenotypes

Berking, Ann-Cathrine ; Thiel, Christiane ; Schiele, Miriam A. ; Baumann, Christian ; Kalisch, Raffael ; Notzon, Swantje ; Zwanzger, Peter ; Pané-Farré, Christiane A. ; Hamm, Alfons O. ; Alpers, Georg W. ; Fydrich, Thomas ; Fehm, Lydia ; Gerlach, Alexander L. ; Straube, Benjamin ; Kircher, Tilo ; Rief, Winfried ; Plag, Jens ; Ströhle, Andreas ; Lang, Thomas ; Wittchen, Hans-Ulrich ; Arolt, Volker ; Romanos, Marcel ; Pauli, Paul ; Reif, Andreas ; Deckert, Jürgen ; Domschke, Katharina ; Weber, Heike

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Document Type: Article
Year of publication: 2020
The title of a journal, publication series: Journal of Neural Transmission
Volume: 127
Issue number: 11
Page range: 1527-1537
Place of publication: Wien [u.a.]
Publishing house: Springer
ISSN: 0300-9564 , 1435-1463
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Publication language: English
Institution: School of Social Sciences > Klinische u. Biologische Psychologie u. Psychotherapie (Alpers 2010-)
Subject: 150 Psychology
610 Medicine and health
Abstract: While DNA methylation patterns have been studied for a role in the pathogenesis of anxiety disorders, the role of the enzymes establishing DNA methylation—DNA methyltransferases (DNMTs)—has yet to be investigated. In an effort to investigate DNMT genotype-specific effects on dimensional anxiety traits in addition to the categorical phenotype of panic disorder, 506 panic disorder patients and 3112 healthy participants were assessed for anxiety related cognition [Agoraphobic Cognitions Questionnaire (ACQ)], anxiety sensitivity [Anxiety Sensitivity Index (ASI)] as well as pathological worry [Penn State Worry Questionnaire (PSWQ)] and genotyped for five single nucleotide polymorphisms (SNPs) in the DNMT3A (rs11683424, rs1465764, rs1465825) and DNMT3B (rs2424932, rs4911259) genes, which have previously been found associated with clinical and trait-related phenotypes. There was no association with the categorical phenotype panic disorder. However, a significant association was discerned between DNMT3A rs1465764 and PSWQ scores in healthy participants, with the minor allele conveying a protective effect. In addition, a marginally significant association between questionnaire scores (PSWQ, ASI) in healthy participants and DNMT3B rs2424932 was detected, again with the minor allele conveying a protective effect. The present results suggest a possible minor role of DNMT3A and DNMT3B gene variation in conveying resilience towards anxiety disorders. As the observed associations indicated a protective effect of two SNPs particularly with pathological worry, future studies are proposed to explore these variants in generalized anxiety disorder rather than panic disorder.
Additional information: Fälschl. "Notzen, Swantje" statt "Notzon, Swantje"

Dieser Eintrag ist Teil der Universitätsbibliographie.

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