Estradiol during (analogue-)trauma: Risk- or protective factor for intrusive re-experiencing?

Franke, Laila Katharina ; Miedl, Stephan Franz ; Danböck, Sarah K. ; Lohse, Johanna ; Liedlgruber, Michael ; Bürkner, Paul-Christian ; Pletzer, Belinda ; Wilhelm, Frank H.

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URN: urn:nbn:de:bsz:180-madoc-652868
Document Type: Article
Year of publication: 2022
The title of a journal, publication series: Psychoneuroendocrinology
Volume: 143
Issue number: Article 105819
Page range: 1-12
Place of publication: Amsterdam [u.a.]
Publishing house: Elsevier
ISSN: 0306-4530 , 1873-3360
Publication language: English
Institution: School of Social Sciences > Klinische u. Biologische Psychologie u. Psychotherapie (Alpers 2010-)
Pre-existing license: Creative Commons Attribution 4.0 International (CC BY 4.0)
Subject: 150 Psychology
610 Medicine and health
Keywords (English): classical conditioning , intrusive memories , posttraumatic stress disorder , estradiol , trauma film
Abstract: Intrusions, a key symptom of posttraumatic stress disorder (PTSD), can occur in the form of images but also as pain sensations. Similar to audiovisual intrusions, the frequency and persistence of pain intrusions varies greatly between individuals. In the current study, we examined whether peritraumatic circulating 17β-estradiol (E2) levels are a biologic factor associated with subsequent audiovisual (i.e., film) and pain intrusion development, and whether peritraumatic stress levels modulate this relationship. Forty-one free-cycling women participated in an ecologically informed trauma-pain-conditioning (TPC) paradigm, using trauma-films and pain as unconditioned stimuli. Independent variables were salivary peritraumatic E2 levels and stress indexed by salivary cortisol and self-reported state-anxiety during TPC. Outcomes were film- and pain-intrusions occurring during daily-life in the week following TPC and a Memory-Triggering-Task in response to conditioned stimuli 24 h after TPC. In the week after analogue-trauma, higher peritraumatic E2 levels were associated with a greater probability of experiencing film-intrusions in the beginning of the week, which switched to a lower probability toward the end of the week. This time-dependent relationship between E2 and film-intrusions only held for higher state-anxious women. In contrast, results indicated a consistent inverse relationship between peritraumatic E2 levels and pain-intrusions during daily-life and Memory-Triggering-Task. Together, these data suggest that higher peritraumatic E2 levels could be associated with lower long-term visual trauma intrusions, as well as lower pain-intrusions, and thereby possibly constitute a protective biologic factor for PTSD and potentially also for chronic pain.

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