Structural neuroimaging of hippocampus and amygdala subregions in posttraumatic stress disorder: A scoping review


Ben-Zion, Ziv ; Korem, Nachshon ; Fine, Naomi B. ; Katz, Sophia ; Siddhanta, Megha ; Funaro, Meliassa C. ; Duek, Or ; Spiller, Tobias R. ; Danböck, Sarah K. ; Levy, Ifat ; Harpaz-Rotem, Ilan


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DOI: https://doi.org/10.1016/j.bpsgos.2023.07.001
URL: https://www.sciencedirect.com/science/article/pii/...
Additional URL: https://www.bpsgos.org/article/S2667-1743(23)00081...
URN: urn:nbn:de:bsz:180-madoc-652830
Document Type: Article
Year of publication: 2024
The title of a journal, publication series: Biological Psychiatry: Global Open Science
Volume: 4
Issue number: 1
Page range: 120-134
Place of publication: Amsterdam
Publishing house: Elsevier
ISSN: 2667-1743
Related URLs:
Publication language: English
Institution: School of Social Sciences > Klinische u. Biologische Psychologie u. Psychotherapie (Alpers 2010-)
Pre-existing license: Creative Commons Attribution, Non-Commercial, No Derivatives 4.0 International (CC BY-NC-ND 4.0)
Subject: 150 Psychology
570 Life sciences, biology
610 Medicine and health
Abstract: Numerous studies have explored the relationship between posttraumatic stress disorder (PTSD) and the hippo-campus and the amygdala because both regions are implicated in the disorder’s pathogenesis and pathophysiology. Nevertheless, those key limbic regions consist of functionally and cytoarchitecturally distinct substructures that may play different roles in the etiology of PTSD. Spurred by the availability of automatic segmentation software, structural neuroimaging studies of human hippocampal and amygdala subregions have proliferated in recent years. Here, we present a preregistered scoping review of the existing structural neuroimaging studies of the hippocampus and amygdala subregions in adults diagnosed with PTSD. A total of 3513 studies assessing subregion volumes were identified, 1689 of which were screened, and 21 studies were eligible for this review (total N = 2876 individuals). Most studies examined hippocampal subregions and reported decreased CA1, CA3, dentate gyrus, and subiculum volumes in PTSD. Fewer studies investigated amygdala subregions and reported altered lateral, basal, and central nuclei volumes in PTSD. This review further highlights the conceptual and methodological limitations of the current literature and identifies future directions to increase understanding of the distinct roles of hippocampal and amygdalar subregions in posttraumatic psychopathology.




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